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・ Cyclidia
・ Cyclidia dictyaria
・ Cyclidia fabiolaria
・ Cyclidia fractifascia
・ Cyclidia javana
・ Cyclidia orciferaria
・ Cyclidia pitmani
・ Cyclidia rectificata
・ Cyclidia sericea
・ Cyclidia substigmaria
・ Cyclidia tetraspota
・ Cyclidiinae
・ Cyclin
・ Cyclin A
・ Cyclin A1
Cyclin A2
・ Cyclin B
・ Cyclin B1
・ Cyclin B2
・ Cyclin D
・ Cyclin D/Cdk4
・ Cyclin D1
・ Cyclin D2
・ Cyclin D3
・ Cyclin E
・ Cyclin E1
・ Cyclin E2
・ Cyclin H
・ Cyclin K
・ Cyclin O


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Cyclin A2 : ウィキペディア英語版
Cyclin A2

Cyclin-A2 is a protein that in humans is encoded by the ''CCNA2'' gene. It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and embryogenesis while cyclin A2 is expressed in dividing somatic cells.
== Function ==

Cyclin A2 belongs to the cyclin family, whose members regulate cell cycle progression by interacting with CDK kinases. Cyclin A2 is unique in that it can activate two different CDK kinases; it binds CDK2 during S phase, and CDK1 during the transition from G2 to M phase.
Cyclin A2 is synthesized at the onset of S phase and localizes to the nucleus, where the cyclin A2-CDK2 complex is implicated in the initiation and progression of DNA synthesis. Phosphorylation of CDC6 and MCM4 by the cyclin A2-CDK2 complex prevents re-replication of DNA during the cell cycle.〔
Cyclin A2 is involved in the G2/M transition but it cannot independently form a maturation promoting factor (MPF). Recent studies have shown that the cyclin A2-CDK1 complex triggers cyclin B1-CDK1 activation which results in chromatin condensation and the breakdown of the nuclear envelope.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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